Systemic deuteration of SCID mice using the water-isotopologue deuterium oxide (D₂ O) inhibits tumor growth in an orthotopic bioluminescent model of human pancreatic ductal adenocarcinoma.

ABSTRACT: Since its initial discovery as a natural isotopologue of dihydrogen oxide (¹ H₂ O), extensive research has focused on the biophysical, biochemical, and pharmacological effects of deuterated water (² H₂ O [D₂ O, also referred to as "heavy water"]). Using a panel of cultured human pancreatic ductal adenocarcinoma (PDAC) cells we have profiled (i) D₂ O-induced phenotypic antiproliferative and apoptogenic effects, (ii) redox- and proteotoxicity-directed stress response gene expression, and (iii) phosphoprotein-signaling related to endoplasmic reticulum (ER) and MAP-kinase stress response pathways. Differential array analysis revealed early modulation of stress response gene expression in both BxPC-3 and PANC-1 PDAC cells elicite

SUBMITTER: Jandova J 

PROVIDER: S-EPMC10106369 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature