Optogenetic disruption of the prelimbic cortex alters long-term decision strategy but not valuation on a spatial delay discounting task.

ABSTRACT: Rats demonstrate a preference for smaller, immediate rewards over larger, delayed ones, a phenomenon known as delay-discounting (DD). Behavior arises from the interaction of multiple decision-making systems, and the medial prefrontal cortex (mPFC) has been identified as a central component in the mediation between these decision systems. To investigate the role of the prelimbic (PL) subregion of mPFC on decision strategy interaction, we compared two cohorts of rats (ChR2-opsin-expressing 'Active' and opsin-absent 'Control') on a spatial delay-discounting task while delivering in-vivo light stimulation into PL at the choice point of select trials. By analyzing the overall delay-adjustment along with deliberative and procedural behavioral strategy markers, our study revealed differences in t

SUBMITTER: McLaughlin AE 

PROVIDER: S-EPMC10106449 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature