Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains.

ABSTRACT:

Introduction

The identification of multiple genetic risk factors for Alzheimer's disease (AD) suggests that many pathways contribute to AD onset and progression. However, the metabolomic and lipidomic profiles in carriers of distinct genetic risk factors are not fully understood. The metabolome can provide a direct image of dysregulated pathways in the brain.

Methods

We interrogated metabolomic signatures in the AD brain, including carriers of pathogenic variants in APP, PSEN1, and PSEN2 (autosomal dominant AD; ADAD), APOE ɛ4, and TREM2 risk variant carriers, and sporadic AD (sAD).

Results

We identified 133 unique and shared metabolites associated with ADAD, TREM2, and sAD. We identified a signature of 16 metabolites significantly altered between groups and associated

SUBMITTER: Novotny BC 

PROVIDER: S-EPMC10106526 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature