Meta-analysis of diagnostic test accuracy studies with multiple thresholds for data integration.

ABSTRACT:

Objectives

The objective of this study is to introduce methods to use all of the information without omission when individual studies provide multiple effect sizes according to multiple cut-off values (thresholds) during diagnostic test accuracy (DTA) for data integration. For diagnostic test meta-analysis, a general performance method for synthesizing data according to one cut value in one study and a performance method for synthesizing data according to two or more cut values in one study were compared and analyzed.

Methods

As sample data for meta-analysis of DTA studies, 13 DTA studies on prostate cancer (34 effect sizes including total cut-offs) were collected. The summary statistics were calculated and the summary line was analyzed using the "meta", "mada", and "diagmet

SUBMITTER: Shim SR 

PROVIDER: S-EPMC10106543 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature