Drugs against metabolic diseases as potential senotherapeutics for aging-related respiratory diseases.

ABSTRACT: Recent advances in aging research have provided novel insights for the development of senotherapy, which utilizes cellular senescence as a therapeutic target. Cellular senescence is involved in the pathogenesis of various chronic diseases, including metabolic and respiratory diseases. Senotherapy is a potential therapeutic strategy for aging-related pathologies. Senotherapy can be classified into senolytics (induce cell death in senescent cells) and senomorphics (ameliorate the adverse effects of senescent cells represented by the senescence-associated secretory phenotype). Although the precise mechanism has not been elucidated, various drugs against metabolic diseases may function as senotherapeutics, which has piqued the interest of the scientific community. Cellular senescence is involv

SUBMITTER: Matsubayashi S 

PROVIDER: S-EPMC10106576 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature