Two small-molecule inhibitors of Toxoplasma gondii proliferation in vitro.

ABSTRACT:

Background

Toxoplasmosis caused by Toxoplasma gondii is a globally distributed zoonosis. Most infections appear asymptomatic in immunocompetent individuals, but toxoplasmosis can be fatal in fetuses and immunocompromised adults. There is an urgent need to research and develop effective and low-toxicity anti-T. gondii drugs because of some defects in current clinical anti-T. gondii drugs, such as limited efficacy, serious side effects and drug resistance.

Methods

In this study, 152 autophagy related compounds were evaluated as anti-T. gondii drugs. The activity of β-galactosidase assay based on luminescence was used to determine the inhibitory effect on parasite growth. At the same time, MTS assay was used to further detect the effects of compounds

SUBMITTER: Hua QQ 

PROVIDER: S-EPMC10106592 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature