Drosophila melanogaster as a model to study age and sex differences in brain injury and neurodegeneration after mild head trauma.

ABSTRACT: Repetitive physical insults to the head, including those that elicit mild traumatic brain injury (mTBI), are a known risk factor for a variety of neurodegenerative conditions including Alzheimer's disease (AD), Parkinson's disease (PD), and chronic traumatic encephalopathy (CTE). Although most individuals who sustain mTBI typically achieve a seemingly full recovery within a few weeks, a subset experience delayed-onset symptoms later in life. As most mTBI research has focused on the acute phase of injury, there is an incomplete understanding of mechanisms related to the late-life emergence of neurodegeneration after early exposure to mild head trauma. The recent adoption of Drosophila-based brain injury models provides several unique advantages over existing preclinical animal models

SUBMITTER: Ye C 

PROVIDER: S-EPMC10106652 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature