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Pathological identification of HER2-low breast cancer: Tips, tricks, and troubleshooting for the optimal test.

ABSTRACT: The introduction of novel anti-HER2 antibody-drug conjugates (ADC) for the treatment of HER2-low breast cancers has transformed the traditional dichotomy of HER2 status to an expanded spectrum. However, the identification of HER2-low (i.e., immunohistochemistry (IHC) score 1 + or IHC score 2+, without gene amplification) tumors is challenged by methodological and analytical variables that might influence the sensitivity and reproducibility of HER2 testing. To open all possible therapeutic opportunities for HER2-low breast cancer patients the implementation of more accurate and reproducible testing strategies is mandatory. Here, we provide an overview of the existing barriers that may trouble HER2-low identification in breast cancer and discuss practical solutions that could enhance HER-low assessment.

SUBMITTER: Sajjadi E

PROVIDER: S-EPMC10106673 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Pathological identification of HER2-low breast cancer: Tips, tricks, and troubleshooting for the optimal test.

Sajjadi Elham E Guerini-Rocco Elena E De Camilli Elisa E Pala Oriana O Mazzarol Giovanni G Venetis Konstantinos K Ivanova Mariia M Fusco Nicola N

Frontiers in molecular biosciences 20230403

The introduction of novel anti-HER2 antibody-drug conjugates (ADC) for the treatment of HER2-low breast cancers has transformed the traditional dichotomy of HER2 status to an expanded spectrum. However, the identification of HER2-low (i.e., immunohistochemistry (IHC) score 1 + or IHC score 2+, without gene amplification) tumors is challenged by methodological and analytical variables that might influence the sensitivity and reproducibility of HER2 testing. To open all possible therapeutic opport ...[more]

PMID: 37077201

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