The causal effect of obesity on diabetic retinopathy: A two-sample Mendelian randomization study.

ABSTRACT:

Background

The causal effect of obesity on diabetic retinopathy (DR) remains controversial. The aim of this study was to assess the causal association of generalized obesity evaluated by body mass index (BMI) and abdominal obesity evaluated by waist or hip circumference with DR, background DR, and proliferative DR using a two-sample Mendelian randomization (MR) analysis.

Methods

Genetic variants associated with obesity at the genome-wide significance (P<5×10^-8) level were derived using GWAS summary statistics from the UK Biobank (UKB) with a sample size of 461 460 individuals for BMI, 462 166 individuals for waist circumference, and 462 117 individuals for hip circumference. We obtained genetic predictors of DR (14 584 cases and 202 082 controls), background DR (2

SUBMITTER: Zheng C 

PROVIDER: S-EPMC10106681 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature