Selective breeding for physical inactivity produces cognitive deficits via altered hippocampal mitochondrial and synaptic function.

ABSTRACT: Physical inactivity is the 4th leading cause of death globally and has been shown to significantly increase the risk for developing Alzheimer's Disease (AD). Recent work has demonstrated that exercise prior to breeding produces heritable benefits to the brains of offspring, suggesting that the physical activity status of previous generations could play an important role in one's brain health and their subsequent risk for neurodegenerative diseases. Thus, our study aimed to test the hypothesis that selective breeding for physical inactivity, or for high physical activity, preference produces heritable deficits and enhancements to brain health, respectively. To evaluate this hypothesis, male and female sedentary Low Voluntary Runners (LVR), wild type (WT), and High Voluntary Runner (HVR) rat

SUBMITTER: Kerr NR 

PROVIDER: S-EPMC10106691 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature