Establishment and validation of exhausted CD8+ T cell feature as a prognostic model of HCC.

ABSTRACT:

Objectives

The exhausted CD8+T (Tex) cells are a unique cell population of activated T cells that emerges in response to persistent viral infection or tumor antigens. Tex cells showed the characteristics of aging cells, including weakened self-renewal ability, effector function inhibition, sustained high expression of inhibitory receptors including PD-1, TIGIT, TIM-3, and LAG-3, and always accompanied by metabolic and epigenetic reprogramming. Tex cells are getting more and more attention in researching immune-related diseases and tumor immunotherapy. However, studies on Tex-related models for tumor prognosis are still lacking. We hope to establish a risk model based on Tex-related genes for HCC prognosis.

Methods

Tex-related GEO datasets from different pathologic factors (c

SUBMITTER: Shi J 

PROVIDER: S-EPMC10106715 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature