A natural history study of paediatric non-alcoholic fatty liver disease over 10 years.

ABSTRACT:

Background & aims

The long-term outcome of paediatric non-alcoholic fatty liver disease (NAFLD) has not been well established. Between 2008 and 2012, an unselected cohort of 133 children with severe obesity was screened for NAFLD. The aim of this study was to determine the 10-year natural history of NAFLD in this cohort.

Methods

All 133 participants of the original study were approached. Proton magnetic resonance spectroscopy (¹H-MRS) and the Enhanced Liver Fibrosis® (ELF) test were used to assess longitudinal changes in steatosis and fibrosis, respectively. Risk factors for disease progression were explored.

Results

Fifty-one of the 133 participants (38%) from the original cohort were included. The mean follow-up time was 10.3 years (range 7-13 years), 65%

SUBMITTER: Draijer L 

PROVIDER: S-EPMC10106916 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature