Ontology highlight
ABSTRACT:
SUBMITTER: Clarke MN
PROVIDER: S-EPMC10106982 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Clarke Matthew N MN Marsoner Theodor T Adell Manuel Alonso Y MAY Ravichandran Madhwesh C MC Campbell Christopher S CS
The EMBO journal 20221219 8
Both an increased frequency of chromosome missegregation (chromosomal instability, CIN) and the presence of an abnormal complement of chromosomes (aneuploidy) are hallmarks of cancer. To better understand how cells are able to adapt to high levels of chromosomal instability, we previously examined yeast cells that were deleted of the gene BIR1, a member of the chromosomal passenger complex (CPC). We found bir1Δ cells quickly adapted by acquiring specific combinations of beneficial aneuploidies. ...[more]