Peripheral Airway Dysfunction in Obesity and Obese Asthma.

ABSTRACT:

Background

The purpose of this study was to investigate physiological phenotypes of asthma in obesity.

Research question

Do physiological responses during bronchoconstriction distinguish different groups of asthma in people with obesity, and also differentiate from responses simply related to obesity?

Study design and methods

Cross-sectional study of people with obesity (31 with asthma and 22 without lung disease). Participants underwent methacholine challenge testing with measurement of spirometry and respiratory system impedance by oscillometry.

Results

Participants had class III obesity (BMI, 46.7 ± 6.6 kg/m² in control subjects and 47.2 ± 8.2 kg/m² in people with asthma). Most participants had significant changes in peripheral airway i

SUBMITTER: Dixon AE 

PROVIDER: S-EPMC10107055 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature