Oxygen treatment reduces neurological deficits and demyelination in two animal models of multiple sclerosis.

ABSTRACT:

Aims

The objective of the study is to explore the importance of tissue hypoxia in causing neurological deficits and demyelination in the inflamed CNS, and the value of inspiratory oxygen treatment, using both active and passive experimental autoimmune encephalomyelitis (EAE).

Methods

Normobaric oxygen treatment was administered to Dark Agouti rats with either active or passive EAE, compared with room air-treated, and naïve, controls.

Results

Severe neurological deficits in active EAE were significantly improved after just 1 h of breathing approximately 95% oxygen. The improvement was greater and more persistent when oxygen was applied either prophylactically (from immunisation for 23 days), or therapeutically from the onset of neurological deficits for 24, 48, or 72 h

SUBMITTER: Amatruda M 

PROVIDER: S-EPMC10107096 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature