CCR5-Δ32 polymorphism-a possible protective factor from gait impairment amongst post-stroke patients.

ABSTRACT:

Background and purpose

Stroke and small vessel disease cause gait disturbances and falls. The naturally occurring loss-of-function mutation in the C-C chemokine receptor 5 gene (CCR5-Δ32) has recently been reported as a protective factor in post-stroke motor and cognitive recovery. We sought to examine whether it also influences gait and balance measures up to 2 years after stroke.

Method

Participants were 575 survivors of first-ever, mild-moderate ischaemic stroke or transient ischaemic attack from the TABASCO prospective study, who underwent a 3 T magnetic resonance imaging at baseline and were examined by a multi-professional team 6, 12 and 24 months after the event, using neurological, neuropsychological and mobility examinations. Gait rhythm and the timing of the gait c

SUBMITTER: Molad J 

PROVIDER: S-EPMC10107159 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature