Dynamics of adipose tissue macrophage populations after gastric bypass surgery.

ABSTRACT:

Objective

This case-control study aimed to analyze the dynamics of macrophage infiltration in subcutaneous adipose tissue following bariatric surgery or conservative treatment of obesity and to clarify whether these features predict the weight loss outcome after the surgery.

Methods

Subcutaneous tissue samples taken before and 12 months after laparoscopic Roux-en-Y gastric bypass surgery (n = 39) or conservative (n = 43) treatment for obesity were analyzed. Fat cell size was determined, and with CD68 immunohistochemistry, crown-like structures (CLS) were counted and single macrophages were quantitated.

Results

A major decline in CLS density from 4.1 (SD 3.5) to 1.1 (SD 0.8) per 1000 fat cells (p < 0.000) was found, regardless of the degree of weight loss after the sur

SUBMITTER: Palomaki VA 

PROVIDER: S-EPMC10107220 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature