Limited role of children in transmission of SARS-CoV-2 virus in households-Immunological analysis of 26 familial clusters.

ABSTRACT:

Background

The impact of children on the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains uncertain. This study provides an insight into distinct patterns of SARS-CoV-2 household transmission in case of pediatric and adult index cases as well as age-dependent susceptibility to SARS-CoV-2 infection.

Methods

Immune analysis, medical interviewing, and contact tracing of 26 families with confirmed SARS-CoV-2 infection cases have been conducted. Blood samples were analyzed serologically with the use of a SARS-CoV-2-specific IgG assay and virus neutralization test (VNT). Uni- and multivariable linear regression and mixed effect logistic regression models were used to describe potential risk factors for higher contagiousness and susceptibility to

SUBMITTER: Sieber J 

PROVIDER: S-EPMC10107319 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature