Injectable adhesive carboxymethyl chitosan-based hydrogels with self-mending and antimicrobial features for the potential management of periodontal diseases.

ABSTRACT: Treating periodontal diseases is a great challenge owing to the motion and wet conditions, bacterial infection, and tissue defects. Therefore, designing bioactive materials with outstanding wet-tissue adhesion, antimicrobial features, as well as favorable cell responses, is highly desirable to meet practical necessity. In this work, bio-multifunctional melatonin-loaded carboxymethyl chitosan/polyaldehyde dextran (CPM) hydrogels have been developed through the dynamic Schiff-base reaction. Our results demonstrate that the CPM hydrogels display injectability, structural stability, and high tissue adhesion in the wet and motional state, as well as self-healing features. In addition, the designed hydrogels show great antibacterial properties and excellent biocompatibility. The prepared hydroge

SUBMITTER: Lin X 

PROVIDER: S-EPMC10107338 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature