Unveiling the Collaborative Effect at the Cucurbit[8]uril-MoS₂ Hybrid Interface for Electrochemical Melatonin Determination.

ABSTRACT: Host-guest interactions are of paramount importance in supramolecular chemistry and in a wide range of applications. Particularly well known is the ability of cucurbit[n]urils (CB[n]) to selectively host small molecules. We show that the charge transfer and complexation capabilities of CB[n] are retained on the surface of 2D transition metal dichalcogenides (TMDs), allowing the development of efficient electrochemical sensing platforms. We unveil the mechanisms of host-guest recognition between the MoS₂ -CB[8] hybrid interface and melatonin (MLT), an important molecular regulator of vital constants in vertebrates. We find that CB[8] on MoS₂ organizes the receptor portals perpendicularly to the surface, facilitating MLT complexation. This advantageous adsorption geomet

SUBMITTER: Martinez-Moro R 

PROVIDER: S-EPMC10107440 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature