Circadian disruption in lung fibroblasts enhances NF-κB activity to exacerbate neutrophil recruitment.

ABSTRACT: Fibroblasts are stromal cells abundant throughout tissues, including the lungs. Fibroblasts are integral coordinators of immune cell recruitment through chemokine secretion. Circadian rhythms direct the recruitment of immune cells to the lung, which in turn impacts response to infection and survival. Although fibroblasts display robust circadian rhythms, the contribution of the fibroblast molecular clock to lung-specific migration of immune cells and recruitment remains to be established. Mice challenged intranasally with lipopolysaccharide (LPS) at dusk showed increased expression of the pro-inflammatory cytokine IL-1β and chemokine CXCL5 in the lung, which was accompanied by increased neutrophil recruitment. Primary lung fibroblasts with knockdown of the core clock gene Bmal1 and immorta

SUBMITTER: Cox SL 

PROVIDER: S-EPMC10107448 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature