Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells.

ABSTRACT: Scattered tubular cells (STCs) are a phenotypically distinct cell population in the proximal tubule that increase in number after acute kidney injury. We aimed to characterize the human STC population. Three-dimensional human tissue analysis revealed that STCs are preferentially located within inner bends of the tubule and are barely present in young kidney tissue (<2 years), and their number increases with age. Increased STC numbers were associated with acute tubular injury (kidney injury molecule 1) and interstitial fibrosis (alpha smooth muscle actin). Isolated CD13⁺ CD24^- CD133^- proximal tubule epithelial cells (PTECs) and CD13⁺ CD24+ and CD13⁺ CD133⁺ STCs were analyzed using RNA sequencing. Transcriptome analysis reveal

SUBMITTER: Eymael J 

PROVIDER: S-EPMC10107692 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature