Consequences of collagen induced inflammatory arthritis on circadian regulation of the gut microbiome.

ABSTRACT: The gut microbiota is important for host health and immune system function. Moreover autoimmune diseases, such as rheumatoid arthritis, are associated with significant gut microbiota dysbiosis, although the causes and consequences of this are not fully understood. It has become clear that the composition and metabolic outputs of the microbiome exhibit robust 24 h oscillations, a result of daily variation in timing of food intake as well as rhythmic circadian clock function in the gut. Here, we report that experimental inflammatory arthritis leads to a re-organization of circadian rhythmicity in both the gut and associated microbiome. Mice with collagen induced arthritis exhibited extensive changes in rhythmic gene expression in the colon, and reduced barrier integrity. Re-modeling of the h

SUBMITTER: Simpkins DA 

PROVIDER: S-EPMC10107696 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature