From passage to inhibition: Uncovering the structural and physiological inhibitory mechanisms of MCUb in mitochondrial calcium regulation.

ABSTRACT: Mitochondrial calcium (Ca²⁺ ) regulation is critically implicated in the regulation of bioenergetics and cell fate. Ca²⁺ , a universal signaling ion, passively diffuses into the mitochondrial intermembrane space (IMS) through voltage-dependent anion channels (VDAC), where uptake into the matrix is tightly regulated across the inner mitochondrial membrane (IMM) by the mitochondrial Ca²⁺ uniporter complex (mtCU). In recent years, immense progress has been made in identifying and characterizing distinct structural and physiological mechanisms of mtCU component function. One of the main regulatory components of the Ca²⁺ selective mtCU channel is the mitochondrial Ca²⁺ uniporter dominant-negative beta subunit (MCUb). The structural mechanis

SUBMITTER: Colussi DM 

PROVIDER: S-EPMC10107711 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature