Connectome-based predictive modelling of cognitive reserve using task-based functional connectivity.

ABSTRACT: Cognitive reserve supports cognitive function in the presence of pathology or atrophy. Functional neuroimaging may enable direct and accurate measurement of cognitive reserve which could have considerable clinical potential. The present study aimed to develop and validate a measure of cognitive reserve using task-based fMRI data that could then be applied to independent resting-state data. Connectome-based predictive modelling with leave-one-out cross-validation was applied to predict a residual measure of cognitive reserve using task-based functional connectivity from the Cognitive Reserve/Reference Ability Neural Network studies (n = 220, mean age = 51.91 years, SD = 17.04 years). This model generated summary measures of connectivity strength that accurately predicted a residual measure

SUBMITTER: Boyle R 

PROVIDER: S-EPMC10107737 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature