Nitrous Oxide, a Rapid Antidepressant, Has Ketamine-like Effects on Excitatory Transmission in the Adult Hippocampus.

ABSTRACT:

Background

Nitrous oxide (N₂O) is a noncompetitive inhibitor of NMDA receptors that appears to have ketamine-like rapid antidepressant effects in patients with treatment-resistant major depression. In preclinical studies, ketamine enhances glutamate-mediated synaptic transmission in the hippocampus and prefrontal cortex. In this study, we examined the effects of N₂O on glutamate transmission in the hippocampus and compared its effects to those of ketamine.

Methods

Glutamate-mediated synaptic transmission was studied in the CA1 region of hippocampal slices from adult albino rats using standard extracellular recording methods. Effects of N₂O and ketamine at subanesthetic concentrations were evaluated by acute administration.

Results

Akin

SUBMITTER: Izumi Y 

PROVIDER: S-EPMC10107749 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature