Neuropsychological features in RASopathies: A pilot study on parent training program involving families of children with Noonan syndrome.

ABSTRACT: Noonan syndrome (NS) is a clinical variable multisystem disorder caused by mutations in genes encoding proteins involved in the RAS/mitogen-activated protein kinase signaling pathway. NS is characterized by a distinctive facies, short stature, and congenital heart defects. Psychomotor delay, learning difficulties, and social deficits are also common. Furthermore, behavioral and attention problems can be reckoned as a key symptom in NS, with functioning resembling the patterns observed in attention deficit hyperactivity disorder (ADHD). The complex behavioral phenotype has great impact on the quality of life and raises demanding management issues also for patients' families. Parent management training (PMT) is recommended as first-line treatment for ADHD; however, no study has been performe

SUBMITTER: Montanaro FAM 

PROVIDER: S-EPMC10107825 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature