Pharmacological inhibition of SK-channels with AP14145 prevents atrial arrhythmogenic changes in a porcine model for obstructive respiratory events.

ABSTRACT:

Background

Obstructive sleep apnea (OSA) creates a complex substrate for atrial fibrillation (AF), which is refractory to many clinically available pharmacological interventions. We investigated atrial antiarrhythmogenic properties and ventricular electrophysiological safety of small-conductance Ca²⁺ -activated K⁺ (SK)-channel inhibition in a porcine model for obstructive respiratory events.

Methods

In spontaneously breathing pigs, obstructive respiratory events were simulated by intermittent negative upper airway pressure (INAP) applied via a pressure device connected to the intubation tube. INAP was applied for 75 s, every 10 min, three times before and three times during infusion of the SK-channel inhibitor AP14145. Atrial effective refractory period

SUBMITTER: Linz B 

PROVIDER: S-EPMC10107889 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature