A universal cell-free DNA approach for response prediction to preoperative chemoradiation in rectal cancer.

ABSTRACT: The standard treatment approach for stage II/III rectal cancer is neoadjuvant chemoradiation therapy (nCRT) followed by surgery. In recent years, new treatment approaches have led to higher rates of complete tumor eradication combined with organ-preservation strategies. However, better tools are still needed to personalize therapy for the individual patient. In this prospective observational study, we analyzed colon-derived cell-free (cf)DNA (c-cfDNA) using a tissue-specific DNA methylation signature, and its association with therapy outcomes. Analyzing plasma samples (n = 303) collected during nCRT from 37 patients with locally advanced rectal cancer (LARC), we identified colon-specific methylation markers that discriminated healthy individuals from patients with untreated LARC (area unde

SUBMITTER: Grinshpun A 

PROVIDER: S-EPMC10108011 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature