Metagenomic characterization of the maternal prenatal gastrointestinal microbiome by pregravid BMI.

ABSTRACT:

Objective

The incidence of women entering into pregnancy with BMI indicating overweight or obesity is rising with concurrent increases in adverse complications such as gestational diabetes. Although several studies have examined the compositional changes to the microbiome across BMI classifications, there has been no investigation regarding changes in microbial function during pregnancy.

Methods

A total of 105 gastrointestinal microbiome biospecimens were used in this analysis. Biospecimens were sequenced by using the Illumina NovaSeq 6000 shotgun metagenomics platform.

Results

Findings indicate an enrichment in microbiota from the phylum Firmicutes across all pregravid BMI groups with a decrease in α diversity in groups with BMI indicating obesity or overweight compa

SUBMITTER: Dreisbach C 

PROVIDER: S-EPMC10108029 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature