Effect of vitamin D supplementation on depression in older Australian adults.

ABSTRACT:

Objectives

To investigate whether vitamin D supplementation reduces depressive symptoms and incidence of antidepressant use.

Methods

We used data from the D-Health Trial (N = 21,315), a randomized double-blind placebo-controlled trial of monthly vitamin D₃ for the prevention of all-cause mortality. Participants were Australians aged 60-84 years. Participants completed the Patient Health Questionnaire (PHQ-9) at 1, 2 and 5 years after randomization to measure depressive symptoms; national prescribing records were used to capture antidepressant use. We used mixed models and survival models.

Results

Analyses of PHQ-9 scores included 20,487 participants (mean age 69·3 years, 46% women); the mean difference (MD) in PHQ-9 score (vitamin D vs. placebo) was 0·02 (9

SUBMITTER: Rahman ST 

PROVIDER: S-EPMC10108111 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature