How Bases Catalyze Diels-Alder Reactions.

ABSTRACT: We have quantum chemically studied the base-catalyzed Diels-Alder (DA) reaction between 3-hydroxy-2-pyrone and N-methylmaleimide using dispersion-corrected density functional theory. The uncatalyzed reaction is slow and is preceded by the extrusion of CO₂ via a retro-DA reaction. Base catalysis, for example, by triethylamine, lowers the reaction barrier up to 10 kcal mol^-1 , causing the reaction to proceed smoothly at low temperature, which quenches the expulsion of CO₂ , yielding efficient access to polyoxygenated natural compounds. Our activation strain analyses reveal that the base accelerates the DA reaction via two distinct electronic mechanisms: i) by the HOMO-raising effect, which enhances the normal electron demand orbital interaction; and ii) by do

SUBMITTER: Yu S 

PROVIDER: S-EPMC10108159 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature