Altered hemodynamics and vascular reactivity in a mouse model with severe pericyte deficiency.

ABSTRACT: Pericytes are the mural cells of the microvascular network that are in close contact with underlying endothelial cells. Endothelial-secreted PDGFB leads to recruitment of pericytes to the vessel wall, but this is disrupted in Pdgfb^ret/ret mice when the PDGFB retention motif is deleted. This results in severely reduced pericyte coverage on blood vessels. In this study, we investigated vascular abnormalities and hemodynamics in Pdgfb^ret/ret mice throughout the cerebrovascular network and in different cortical layers by in vivo two-photon microscopy. We confirmed that Pdgfb^ret/ret mice are severely deficient in pericytes throughout the vascular network, with enlarged brain blood vessels and a reduced number of vessel branches. Red b

SUBMITTER: Stobart JL 

PROVIDER: S-EPMC10108184 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature