Blood-brain barrier disruption measured by albumin index correlates with inflammatory fluid biomarkers.

ABSTRACT: Blood-brain barrier (BBB) permeability can be measured by the ratio of albumin in cerebrospinal fluid (CSF) and blood and by dynamic contrast-enhanced MRI (DCEMRI). Albumin is a large molecule measured in CSF and blood to form the albumin index (Q_alb), which is a global measure of BBB permeability, while the smaller Gadolinium molecule measures regional transfer (K_trans); few studies have directly compared them in the same patients. We used both methods as part of a study of mechanisms of white matter injury in patients with different forms of dementia. In addition, we also measured biomarkers for inflammation, including proteases, angiogenic growth factors, and cytokines, and correlated them with the BBB results. We found that there was no correlation between Q_a

SUBMITTER: Hillmer L 

PROVIDER: S-EPMC10108191 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature