Survival in adult patients with chronic primary and secondary immune thrombocytopenia: A population-based study.

ABSTRACT:

Background

Few studies have investigated long-term survival in patients with primary immune thrombocytopenia (pITP). Further, changes in prognosis over the past decades and prognosis of secondary immune thrombocytopenia (sITP) are largely unstudied. Our objectives were to study comorbidity-adjusted prognostic changes and causes of death in chronic pITP and sITP patients.

Study design/methods

Using nationwide Danish health registries 1980-2016, we identified 1762 patients with chronic pITP (median age 58 (IQR, 37-73) years) and 128 with chronic sITP (median age 59 (IQR, 40-73) years). Patients were age-sex-matched to 74,781 general population comparators. Comorbidity was assessed using Charlson Comorbidity Index (CCI).

Results

Overall median survival was reduced by 5.1

SUBMITTER: Mannering N 

PROVIDER: S-EPMC10108240 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature