Experimental models of bone marrow lesions in ovine femoral condyles.

ABSTRACT:

Objective

To develop an in vivo experimental model for bone marrow lesions (BMLs) in ovine femorotibial joints.

Study design

Randomized, prospective experimental study.

Animals

Eighteen healthy, skeletally-mature Dorper cross ewes.

Methods

One medial femoral condyle was penetrated with a 1.1 mm pin, and the contralateral medial femoral condyle was treated with transcutaneous extracorporeal shockwave (ESW) at 0.39 ± 0.04 mJ/mm² . Clinical examination, magnetic resonance imaging (MRI), computed tomography (CT), and histopathological analyses were used to detect and characterize the development and progression of BMLs in the medial femoral condyle at 4, 8, and 12 weeks post-surgery.

Results

Pin penetration induced a BML detected on MRI within 2 w

SUBMITTER: Stewart HL 

PROVIDER: S-EPMC10108275 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature