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A tribute to Howard Rachlin and his two-parameter discounting model: Reliable and flexible model fitting.

ABSTRACT: Delay discounting reflects the rate at which a reward loses its subjective value as a function of delay to that reward. Many models have been proposed to measure delay discounting, and many comparisons have been made among these models. We highlight the two-parameter delay discounting model popularized by Howard Rachlin by demonstrating two key practical features of the Rachlin model. The first feature is flexibility; the Rachlin model fits empirical discounting data closely. Second, when compared with other available two-parameter discounting models, the Rachlin model has the advantage that unique best estimates for parameters are easy to obtain across a wide variety of potential discounting patterns. We focus this work on this second feature in the context of maximum likelihood, showing the relative ease with which the Rachlin model can be utilized compared with the extreme care that must be used with other models for discounting data, focusing on two illustrative cases that pass checks for data validity. Both of these features are demonstrated via a reanalysis of discounting data the authors have previously used for model selection purposes.

SUBMITTER: Franck CT

PROVIDER: S-EPMC10108293 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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A tribute to Howard Rachlin and his two-parameter discounting model: Reliable and flexible model fitting.

Franck Christopher T CT Traxler Haily K HK Kaplan Brent A BA Koffarnus Mikhail N MN Rzeszutek Mark J MJ

Journal of the experimental analysis of behavior 20221214 1

Delay discounting reflects the rate at which a reward loses its subjective value as a function of delay to that reward. Many models have been proposed to measure delay discounting, and many comparisons have been made among these models. We highlight the two-parameter delay discounting model popularized by Howard Rachlin by demonstrating two key practical features of the Rachlin model. The first feature is flexibility; the Rachlin model fits empirical discounting data closely. Second, when compar ...[more]

PMID: 36516020

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Project description:BackgroundStriking a balance between the degree of model complexity and parameter identifiability, while still producing biologically feasible simulations using modelling is a major challenge in computational biology. While these two elements of model development are closely coupled, parameter fitting from measured data and analysis of model mechanisms have traditionally been performed separately and sequentially. This process produces potential mismatches between model and data complexities that can compromise the ability of computational frameworks to reveal mechanistic insights or predict new behaviour. In this study we address this issue by presenting a generic framework for combined model parameterisation, comparison of model alternatives and analysis of model mechanisms.ResultsThe presented methodology is based on a combination of multivariate metamodelling (statistical approximation of the input-output relationships of deterministic models) and a systematic zooming into biologically feasible regions of the parameter space by iterative generation of new experimental designs and look-up of simulations in the proximity of the measured data. The parameter fitting pipeline includes an implicit sensitivity analysis and analysis of parameter identifiability, making it suitable for testing hypotheses for model reduction. Using this approach, under-constrained model parameters, as well as the coupling between parameters within the model are identified. The methodology is demonstrated by refitting the parameters of a published model of cardiac cellular mechanics using a combination of measured data and synthetic data from an alternative model of the same system. Using this approach, reduced models with simplified expressions for the tropomyosin/crossbridge kinetics were found by identification of model components that can be omitted without affecting the fit to the parameterising data. Our analysis revealed that model parameters could be constrained to a standard deviation of on average 15% of the mean values over the succeeding parameter sets.ConclusionsOur results indicate that the presented approach is effective for comparing model alternatives and reducing models to the minimum complexity replicating measured data. We therefore believe that this approach has significant potential for reparameterising existing frameworks, for identification of redundant model components of large biophysical models and to increase their predictive capacity.

Dataset Information

A tribute to Howard Rachlin and his two-parameter discounting model: Reliable and flexible model fitting.

Publications

A tribute to Howard Rachlin and his two-parameter discounting model: Reliable and flexible model fitting.

Similar Datasets

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