Modulation of ERK5 Activity as a Therapeutic Anti-Cancer Strategy.
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ABSTRACT:
SUBMITTER: Miller DC
PROVIDER: S-EPMC10108346 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Publications
Modulation of ERK5 Activity as a Therapeutic Anti-Cancer Strategy.
Miller Duncan C DC Harnor Suzannah J SJ Martin Mathew P MP Noble Richard A RA Wedge Stephen R SR Cano Celine C
Journal of medicinal chemistry 20230401 7
The extracellular signal-regulated kinase 5 (ERK5) signaling pathway is one of four conventional mitogen-activated protein (MAP) kinase pathways. Genetic perturbation of ERK5 has suggested that modulation of ERK5 activity may have therapeutic potential in cancer chemotherapy. This Miniperspective examines the evidence for ERK5 as a drug target in cancer, the structure of ERK5, and the evolution of structurally distinct chemotypes of ERK5 kinase domain inhibitors. The emerging complexities of ERK ...[more]
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