LIGHT-SABRE Hyperpolarizes 1-¹³C-Pyruvate Continuously without Magnetic Field Cycling.

ABSTRACT: Nuclear spin hyperpolarization enables real-time observation of metabolism and intermolecular interactions in vivo. 1-¹³C-pyruvate is the leading hyperpolarized tracer currently under evaluation in several clinical trials as a promising molecular imaging agent. Still, the quest for a simple, fast, and efficient hyperpolarization technique is ongoing. Here, we describe that continuous, weak irradiation in the audio-frequency range of the ¹³C spin at the 121 μT magnetic field (approximately twice Earth's field) enables spin order transfer from parahydrogen to ¹³C magnetization of 1-¹³C-pyruvate. These so-called LIGHT-SABRE pulses couple nuclear spin states of parahydrogen and pyruvate via the J-coupling network of reversibly exchangin

SUBMITTER: Pravdivtsev AN 

PROVIDER: S-EPMC10108362 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature