Protective properties of extracellular vesicles in sepsis models: a systematic review and meta-analysis of preclinical studies.

ABSTRACT:

Background

Multiple preclinical studies have reported a beneficial effect of extracellular vesicles (EVs), especially mesenchymal stem cells derived EVs (MSC-EVs), in the treatment of sepsis. However, the therapeutic effect of EVs is still not universally recognized. Therefore, we conducted this meta-analysis by summarizing data from all published studies that met certain criteria to systematically review the association between EVs treatment and mortality in animal models of sepsis.

Methods

Systematic retrieval of all studies in PubMed, Cochrane and Web of Science that reported the effects of EVs on sepsis models up to September 2022. The primary outcome was animal mortality. After screening the eligible articles according to inclusion and exclusion criteria, the inverse va

SUBMITTER: Yang S 

PROVIDER: S-EPMC10108460 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature