A study on the anti-osteoporosis mechanism of isopsoralen based on network pharmacology and molecular experiments.

ABSTRACT:

Objective

Osteoporosis (OP) is a disease caused by multiple factors. Studies have pointed out that isopsoralen (IPRN) is one of the most effective drugs for the treatment of OP. Based on network pharmacological and molecular experimental analysis, the molecular mechanism of IPRN in osteoporosis is clarified.

Methods

IPRN target genes and OP-related genes were predicted from the databases. Intersections were obtained and visualized. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed on target genes, which was confirmed by experiments internal and external experiments. Molecular docking was used to verify the binding between IPRN and target proteins. Molecular dynamics (MD) simulates the binding affinity of protein targets

SUBMITTER: Wang J 

PROVIDER: S-EPMC10108469 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature