Type 1 diabetes and diet-induced obesity predispose C57BL/6J mice to PM_2.5-induced lung injury: a comparative study.

ABSTRACT:

Background

Pre-existing metabolic diseases may predispose individuals to particulate matter (PM)-induced adverse health effects. However, the differences in susceptibility of various metabolic diseases to PM-induced lung injury and their underlying mechanisms have yet to be fully elucidated.

Results

Type 1 diabetes (T1D) murine models were constructed by streptozotocin injection, while diet-induced obesity (DIO) models were generated by feeding 45% high-fat diet 6 weeks prior to and throughout the experiment. Mice were subjected to real-ambient PM exposure in Shijiazhuang City, China for 4 weeks at a mean PM_2.5 concentration of 95.77 µg/m³. Lung and systemic injury were assessed, and the underlying mechanisms were explored through transcriptomics analys

SUBMITTER: Chen S 

PROVIDER: S-EPMC10108512 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature