Metabolic independence drives gut microbial colonization and resilience in health and disease.

ABSTRACT:

Background

Changes in microbial community composition as a function of human health and disease states have sparked remarkable interest in the human gut microbiome. However, establishing reproducible insights into the determinants of microbial succession in disease has been a formidable challenge.

Results

Here we use fecal microbiota transplantation (FMT) as an in natura experimental model to investigate the association between metabolic independence and resilience in stressed gut environments. Our genome-resolved metagenomics survey suggests that FMT serves as an environmental filter that favors populations with higher metabolic independence, the genomes of which encode complete metabolic modules to synthesize critical metabolites, including amino acids, nucleotides, and vi

SUBMITTER: Watson AR 

PROVIDER: S-EPMC10108530 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature