Clinical thresholds in pain-related facial activity linked to differences in cortical network activation in neonates.

ABSTRACT:

Abstract

In neonates, a noxious stimulus elicits pain-related facial expression changes and distinct brain activity as measured by electroencephalography, but past research has revealed an inconsistent relationship between these responses. Facial activity is the most commonly used index of neonatal pain in clinical settings, with clinical thresholds determining if analgesia should be provided; however, we do not know if these thresholds are associated with differences in how the neonatal brain processes a noxious stimulus. The objective of this study was to examine whether subclinical vs clinically significant levels of pain-related facial activity are related to differences in the pattern of nociceptive brain activity in preterm and term neonates. We recorded whole-head electroenc

SUBMITTER: Bucsea O 

PROVIDER: S-EPMC10108588 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature