Cell-specific effects of the sole C. elegans Daughterless/E protein homolog, HLH-2, on nervous system development.

ABSTRACT: Are there common mechanisms of neurogenesis used throughout an entire nervous system? We explored to what extent canonical proneural class I/II bHLH complexes are responsible for neurogenesis throughout the entire Caenorhabditis elegans nervous system. Distinct, lineage-specific proneural class II bHLH factors are generally thought to operate via interaction with a common, class I bHLH subunit, encoded by Daughterless in flies, the E proteins in vertebrates and HLH-2 in C. elegans. To eliminate function of all proneuronal class I/II bHLH complexes, we therefore genetically removed maternal and zygotic hlh-2 gene activity. We observed broad effects on neurogenesis, but still detected normal neurogenesis in many distinct neuron-producing lineages of the central and peripheral nervous system.

SUBMITTER: Masoudi N 

PROVIDER: S-EPMC10108603 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature