Collagen V deficiency during murine tendon healing results in distinct healing outcomes based on knockdown severity.

ABSTRACT: Tendon function is dependent on proper organization and maintenance of the collagen I tissue matrix. Collagen V is a critical regulator of collagen I fibrils, and while prior studies have shown a negative impact of collagen V deficiency on tendon healing outcomes, these studies are confounded by collagen V deficiency through tendon development. The specific role of collagen V in regulating healing tendon properties is therefore unknown. By using inducible Col5a1 knockdown models and analyzing gene expression, fibril and histological tendon morphology, and tendon mechanical properties, this study defines the isolated role of collagen V through tendon healing. Patellar tendon injury caused large changes in tendon gene expression, and Col5a1 knockdown resulted in dysregulated expression of se

SUBMITTER: Leiphart RJ 

PROVIDER: S-EPMC10108665 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature