Establishment and characterization of a multi-drug resistant cell line for canine mammary tumors.

ABSTRACT:

Background and purpose

Canine mammary tumors are the most common tumor disease of female dogs, and adjuvant chemotherapy often results in multi-drug resistance. Currently, the mechanisms underlying the development of tumor multi-drug resistance are unclear. The translation of research applications that can be used to effectively overcome tumor resistance is similarly hampered. Therefore, it is urgent to construct multi-drug resistance models of canine mammary tumors that can be used for research, to explore the mechanisms and means of overcoming resistance.

Materials and methods

In this study, the canine triple negative breast cancer cell line CMT-7364 was induced to develop multidrug resistance using doxorubicin by high-dose drug pulse method. The drug resistance and the ex

SUBMITTER: Zhou C 

PROVIDER: S-EPMC10108679 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature