Transporter Associated with Antigen Processing 1 Gene Polymorphisms Increase the Susceptibility to Tuberculosis.

ABSTRACT:

Purpose

Tuberculosis (TB) is known to result from a complex interaction between the host immune response and Mycobacterium infection. The transporter associated with antigen processing (TAP) plays an important role in the processing and presentation pathways for the Mycobacterium tuberculosis (M. tb) antigen. To investigate the possible association of the TAP1 and TAP2 genes with TB.

Patients and methods

A total of 449 TB patients and 435 control subjects were included in this study, and single nucleotide polymorphisms (SNPs) in the TAP gene, as well as TAP1 and TAP2 alleles, were genotyped.

Results

TAP gene association analysis of TB diseases showed that rs41551515-T in the TAP1 gene was significan

SUBMITTER: Lu T 

PROVIDER: S-EPMC10108862 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature