The gut microbiome is a significant risk factor for future chronic lung disease.

ABSTRACT:

Background

The gut-lung axis is generally recognized, but there are few large studies of the gut microbiome and incident respiratory disease in adults.

Objective

We sought to investigate the association and predictive capacity of the gut microbiome for incident asthma and chronic obstructive pulmonary disease (COPD).

Methods

Shallow metagenomic sequencing was performed for stool samples from a prospective, population-based cohort (FINRISK02; N = 7115 adults) with linked national administrative health register-derived classifications for incident asthma and COPD up to 15 years after baseline. Generalized linear models and Cox regressions were used to assess associations of microbial taxa and diversity with disease occurrence. Predictive models were constructed using ma

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10109092 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature