Linking autism spectrum disorders and parkinsonism: clinical and genetic association.

ABSTRACT:

Background

Autism spectrum disorders (ASD) comprise many complex and clinically distinct neurodevelopmental conditions, with increasing evidence linking them to parkinsonism.

Methods

We searched Medline and Embase from inception to 21 March 2022 and reviewed the bibliographies of relevant articles. Studies were screened and reviewed comprehensively by two independent authors.

Results

Of 863 references from our search, we included eight clinical studies, nine genetic studies, and five case reports. Regardless of age group, Parkinson's disease (PD) and parkinsonian syndromes were more frequently observed in patients with ASD, though the evidence for increased rates of parkinsonism is less clear for children and adolescents. Parkinsonian features and hypokinetic behavior

SUBMITTER: Mai AS 

PROVIDER: S-EPMC10109258 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature